Skip to main content


Divisions & Teams

RIKEN BRC conducts the following three Programs:

  1. Bioresource Infrastructure Program focusing on five important bioresources of the world’s highest level and their associated information.
  2. Key Technology Development Program in order to effectively, efficiently and sustainably conduct the Bioresource Infrastructure Program.
  3. Bioresource Frontier Program in order to respond appropriately and timely to social and research trends and needs.

Bioresource Infrastructure Program

Six Divisions in these programs conduct R&D to improve infrastructure of the respective bioresources and associated information.

Atsushi Yoshiki, Ph.D.

Experimental Animal Division

Atsushi Yoshiki, Ph.D.

Animal models for understanding of sophisticated life phenomena, promoting human health and conquering diseases
R&D: Genome-edited KO and KI mice

Masatomo Kobayashi, Ph.D.

Experimental Plant Division

Masatomo Kobayashi, Ph.D.

Maximizing the power of plants
R&D: Stress response

Yukio Nakamura, M.D., Ph.D.

Cell Engineering Division

Yukio Nakamura, M.D., Ph.D.

From basic life science research, clinical research to innovation
R&D: Hematopoietic stem cells

Yoshihiro Miwa, Ph.D.

Gene Engineering Division

Yoshihiro Miwa, Ph.D.

Learn from living things and use their power
R&D: Expression vectors with tissue-specific makers

Moriya Ohkuma, Ph.D.

Microbe Division

Moriya Ohkuma, Ph.D.

Promotion of researches on health and environment
R&D: Isolation, identification and characterization of microbes involved in symbiosis

No Information, No Resource
R&D: Visualize analyzed results of genome information, disease states and images of biological dynamism, and develop novel methods for utilization of bioresources

Masatomo Kobayashi, Ph.D.

Support Unit for Quality Management

Masatomo Kobayashi, Ph.D.

To ensure that BRC continues to be trusted by users
Business: Achieving the world’s highest level of quality of bioresources through the PDCA cycle in cooperation with Divisions

Key Technology Development Program

We execute research and development strategies to create the key technologies necessary for bioresource infrastructure. Specifically, we are developing techniques for cryopreservation, nuclear transfer, ICSI, and generation of mouse models and high-quality stem cell lines in mice.

Atsuo Ogura, D.V.M.,Ph.D.

Bioresource Engineering Division

Atsuo Ogura, D.V.M.,Ph.D.

Research and development of technologies for embryo manipulation and stem cells
R&D: The Bioresource Engineering Division aims to develop genetics-related technologies, especially those essential for maintenance and supply of laboratory mice and stem cell lines at a high quality (cryopreservation, nuclear transfer, microinsemination (ICSI), stem cell establishment and production of model animals).

Masaru Tamura, Ph.D.

Mouse Phenotype Analysis Division

Masaru Tamura, Ph.D.

Japan Mouse Clinic
R&D: Mouse Phenotype Analysis Division develops “Mouse Clinic” which is a phenotype analysis platform for genetically modified mice that systematically examines more than 400 items, aiming to understand the pathology of human diseases and elucidate gene functions.

Bioresource Frontier Program

Based on the strength of our five world-class bioresources, we conduct research and development projects that promote breakthroughs in the life sciences, through internal and external collaborations with academia and companies.

Haruhisa Inoue, M.D.,Ph.D.
Keihanna Satellite

iPSC-based Drug Discovery and Development Team

Haruhisa Inoue, M.D.,Ph.D.

Facilitating practical and general uses of disease-specific iPS cells
R&D: iPSC-based Drug Discovery and Development Team works to establish drug discovery and development by utilizing disease-specific iPS cells.

  1. Using iPS cells of RIKEN BRC to develop infrastructure technology for drug discovery and development
  2. Innovating the technology that will open an avenue for practical and general uses
  3. Bridging disease-specific iPS cells and academia / industry in the field of translational research

iPS Cell Advanced Characterization and Development

  1. Advanced characterization of iPSC lines available from RIKEN BRC
  2. Generation of modified iPSC lines
  3. Disease modeling and drug development using disease-specific iPSC lines
  4. Mechanisms of reprogramming
  5. Development of new technologies on cell culture, handling, and analysis

Next Generation Human Disease Modeling
R&D: The Next Generation Human Disease Model Team develops disease model mice and evaluates disease states for intractable diseases designated by the Ministry of Health, Labor and Welfare in Japan, as well as diseases with large social burdens such as age-related diseases and lifestyle-related diseases. Due to advances in genome analysis technology, many patient-specific disease variants have been found. However, it is still unclear how these variants are involved in the pathogenesis.

Plant-Microbe Symbiosis Research and Development
R&D: The Plant-Microbe Symbiosis Research and Development Team develops a digital twin to simulate agroecosystem in cyberspace and bioresources for plant symbiosis microorganisms to contribute to agricultural applications.

The General Outline of the Center

Topics on Bioresources