Research and Development

Bioresource Frontier Programs

Each team in this Programs conducts R&D on bioresources to approach academically important issues such as understanding sophisticated life phenomena, aging and symbiosis as well as socially urgent issues such as curring intractable diseases and age-related diseases, drug discovery and food production.

Innovation of bioresource characteristics analysis technology and utilization method

picture of bioresource characteristics analysis

Technology and Development Team for Mammalian Genome Dynamics develops technologies and experimental tools/ resources for characterization of ‘genotype, epigenotype and phenotype’ of biological resources. Through these efforts, the Team aims to develop extend utilities of bioresources collected at RIKEN BRC. The Team is currently focusing on the single cell analysis that reveals the total characteristics of tissues and organs from molecular profiles of individual cells, machine learning of cell images to identify cell types, quantitative definition of “standard morphology” of cells, application of these technologies to test cell differentiation states and/or multipotency of stem cells and inference of molecular state in combination of imaging and single cell analysis.

Link to Technology and Development Team for Mammalian Genome Dynamics

Japan Mouse Clinic

picture of female researcher wearing white garment

Technology and Development Teams for Mouse Phenotype Analysis develops “Mouse Clinic” which is a phenotype analysis platform for genetically modified mice that systematically examines more than 400 items, aiming to understand the pathology of human diseases and elucidate gene functions. The Team participates in the International Mouse Phenotyping Consortium (IMPC), publishes the results of the phenotype analyses, and develops new technologies on phenotyping analyses.

Link to Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic

Facilitating practical and general uses of disease-specific iPS cells

iPSC-based Drug Discovery and Development Team works to establish drug discovery and development by utilizing disease-specific iPS cells.

  1. Using iPS cells of RIKEN BRC to develop infrastructure technology for drug discovery and development
  2. Innovating the technology that will open an avenue for practical and general uses
  3. Bridging disease-specific iPS cells and academia / industry in the field of translational research
iPSC culture Differentiation technology Disease modeling Compound screening and evaluation pathomechanism healthy control disease functional analysis differentiation Drug discovery and development
Link to iPSC-based Drug Discovery and Development Team

iPS Cell Advanced Characterization and Development

picture of iPS Cell

iPS Cell Advanced Characterization and Development Team is tackling following researches:

  1. Advanced characterization of iPSC lines available from RIKEN BRC
  2. Generation of modified iPSC lines
  3. Disease modeling and drug development using disease-specific iPSC lines
  4. Mechanisms of reprogramming
  5. Development of new technologies on cell culture, handling, and analysis
Link to iPS Cell Advanced Characterization and Development Team

Next Generation Human Disease Modeling

The Next Generation Human Disease Model Team develops disease model mice and evaluates disease states for intractable diseases designated by the Ministry of Health, Labor and Welfare in Japan, as well as diseases with large social burdens such as age-related diseases and lifestyle-related diseases. Due to advances in genome analysis technology, many patient-specific disease variants have been found. However, it is still unclear how these variants are involved in the pathogenesis. We will contribute to the realization of personalized and optimized medicine through a disease modeling project using mice.

Link to Next Generation Human Disease Model Team

Plant-Microbe Symbiosis Research and Development

picture of plant sprout coming out

The Plant-Microbe Symbiosis Research and Development Team develops resources for rhizosphere microorganisms and experimental plants that contribute to plant-microbe symbiosis researches, establishment of experimental systems for plant-microbe symbiosis, and development of informational infrastructure to contribute agricultural applications. By close collaboration with internal and external research communities, we aim to elucidate the mechanisms of symbiotic phenomena and build a research infrastructure that leads to industrial use.

Link to Plant-Microbe Symbiosis Research and Development Team

The General Outline of the Center

The General Outline of the Center > Divisions and Teams