RIKEN BioResource Research Center (BRC) is a unique repository in the world, as it collects and distributes bioresources of three different levels, i.e., genetic materials (genomic and cDNA clones) and cell lines of human and animal origins as well mouse strains. With this unique feature, RIKEN BRC hopes to contribute to the comprehensive research and development on COVID-19. The research and developments have been focusing on the following four subjects: 1) SARS-CoV-2 infection and proliferation, 2) Pathogenesis and host defense, 3) Disease progression to clinically severe cases and 4) Development of effective therapies of COVID-19 patients and preventive vaccines against SARS-CoV-2 infection.
Lists of mouse strains, cell lines and DNA clones useful for COVID-19 R&D from RIKEN BRC are available from following links:
RIKEN BRC has joined to the The Global Mouse Models for COVID-19 Consortium (GMMCC) which consists of research centers and repositories for mouse genetics, genomics, and functional assessment. The GMMCC underpin global research into COVID-19 and SARS-CoV-2 by the efficient delivery of relevant mouse strains, mouse genetics expertise, as well as by dispatching information on outcome, therapeutic effects and safety testing platforms. RIKEN BRC also joined to the COVID-19 Data Portal Japan which is a part of a global effort to accelerate coronavirus research.