RIKEN BioResource Research Center Mouse Mail News (E-mail ver.) No. 174 (dummy)
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RIKEN BioResource Research Center Mouse Mail News (e-mail version) No. 174
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A fruitful fall. There was news of Dr. Akira Yoshino’s Nobel Prize in Chemistry.
I am very happy and proud to have a Japanese Nobel Prize winner this year.
The latest information from RIKEN BRC Laboratory Animal Development Office.
━━━━ Next Next ━━━━━━━━━━━━━━━━━━━━━━━━
● Special feature Mouse of the month
“Mice expressing 3xFLAG-dCas9 useful for analyzing molecular interactions on specific genomic regions”
● Today’s tool for functional analysis
● October 28 (Monday) Announcement of establishment anniversary
● Participation report: INFRAFRONTIER satellite workshop at the IMGC 2019
● User achievements
● Newly deposited mouse strain
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特集 Special Feature Mouse of the Month (October 2019)
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3xFLAG-dCas9 expressing mice useful for analyzing molecular interactions on specific genomic regions
RBRC10188 C57BL / 6-Gt (ROSA) 26Sor
RBRC10189 C57BL / 6-Gt (ROSA) 26Sor
RBRC10190 C57BL / 6-Gt (ROSA) 26Sor
Depositary: Prof. Hotaka Fujii (Graduate School of Medicine, Hirosaki University)
Click here for details
https://mus.brc.riken.jp/en/mouse_of_month/oct_2019_mm
This month’s mouse back number
https://mus.brc.riken.jp/en/mouse_of_month
If you would like to post on the mouse this month, Laboratory Animal Development Office (animal@brc.riken.jp)
Please contact us.
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┃ Today’s tool for functional analysis
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Intracellular oxidative stress imaging mouse
RBRC05704 C57BL / 6J-Tg (3xARE / TK-NRF2 / luc) M2Tiw
RBRC06161 C57BL / 6J-Tg (3xARE / TK-NRF2 / venus) F4Tiw
Mice that can conditionally control increased ROS production
RBRC09859 C57BL / 6J-Tg (CMV-cat, -SDHA <*> / Y215F) 1Hom
Sperm-egg membrane fusion imaging mouse
RBRC05763 STOCK Izumo1 Tg (Clgn-Izumo1 / mCherry) Osb Tg (CAG / Acr-EGFP) C3-N01-FJ002Osb
Sperm acrosome-GFP: sperm mitochondria-DsRed double reporter mouse
RBRC03743 B6D2-Tg (CAG / Su9-DsRed2, Acr3-EGFP) RBGS002Osb
RBRC05861 B6.Cg-Tg (CAG / Su9-DsRed2, Acr3-EGFP) RBGS002Osb
Today’s tool for functional analysis
https://mus.brc.riken.jp/en/todays_tool_and_model
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28 October 28 (Monday) Announcement of establishment anniversary
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October 28 (Monday) will be closed for the anniversary of establishment.
We apologize for the inconvenience and thank you for your understanding.
https://en.brc.riken.jp/news/notice_20191015_01.html
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報告 Participation report: INFRAFRONTIER satellite workshop at the IMGC 2019
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Participation report: INFRAFRONTIER satellite workshop at the IMGC 2019
https://en.brc.riken.jp/news/report_20191008_01.html
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成果 User achievements
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Research results using mice provided by RIKEN BRC have been announced one after another.
RIKEN BRC wants to help you discover new things by introducing your achievements
am thinking. If you have published a paper or obtained a patent, please contact us.
Doing.
RBRC00445 C57BL / 6-Tg (CAG / Acr-EGFP) C3-N01-FJ002Osb
Fukunaga H, Kaminaga K, Sato T, Butterworth KT, Watanabe R, Usami N,
Ogawa T, Yokoya A, Prize KM.
High-precision microbeam radiotherapy reveals testicular tissue-sparing
effects for male fertility preservation.
Sci Rep .; 9 (1): 12618, doi: 10.1038 / s41598-019-48772-3, 2019.
https://doi.org/10.1038/s41598-019-48772-3
RBRC00753 B6; 129P2-Sema4d / Rbrc
Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W.
CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck
squamous cell carcinoma and promotes metastasis.
Cancer Lett .; 455: 1-13, doi: 10.1016 / j.canlet.2019.04.013, 2019.
https://doi.org/10.1016/j.canlet.2019.04.013
RBRC01834 C57BL / 6-Tg (CAG-flpe) 36Ito / ItoRbrc
Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y,
Kunimura K, Kamikaseda Y, Furue M, Fukui Y.
Selective role of neurokinin B in IL-31-induced itch response in mice.
J Allergy Clin Immunol .; 144 (4): 1130-1133.e8, doi: 10.1016 / j.jaci. 2019.06.031, 2019.
https://doi.org/10.1016/j.jaci.2019.06.031
RBRC05555 B6; B6129-Ezh2 / Hko [B6-Ezh2 floxed]
Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M,
Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N,
Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A,
Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.
Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type
Diffuse Astrocytic Gliomas.
Cancer Res .; 79 (19): 4814-4827, doi: 10.1158 / 0008-5472. CAN-19-1272, 2019.
https://doi.org/10.1158/0008-5472.CAN-19-1272
RBRC05663 B6.Cg-Bcl6
Otsuka K, Yamada A, Saito M, Ushio A, Sato M, Kisoda S, Shao W,
Tsunematsu T, Kudo Y, Arakaki R, Ishimaru N.
Ascl2-Regulated Follicular Helper T Cells Promote Autoimmunity
in a Murine Model for Sjögren’s Syndrome.
Am J Pathol., Doi: 10.1016 / j.ajpath.2019.08.008, 2019.
https://doi.org/10.1016/j.ajpath.2019.08.008
RBRC05704 C57BL / 6J-Tg (3xARE / TK-NRF2 / luc) M2Tiw
Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K,
Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K,
Baird L, Yamamoto M.
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap 1.
Cell Rep .; 28 (3): 746-758.e4, doi: 10.1016 / j.celrep. 2019.06.047, 2019.
https://doi.org/10.1016/j.celrep.2019.06.047
RBRC06344 C57BL / 6-App
Hamaguchi T, Tsutsui-Kimura I, Mimura M, Saito T, Saido TC, Tanaka KF.
AppNL-G-F / NL-G-F mice overall do not show impaired motivation,
but cored amyloid plaques in the striatu