{"id":12958,"date":"2026-03-31T15:38:20","date_gmt":"2026-03-31T06:38:20","guid":{"rendered":"http:\/\/web.brc.riken.jp\/ja\/?post_type=news&#038;p=12958"},"modified":"2026-04-02T15:39:03","modified_gmt":"2026-04-02T06:39:03","slug":"20260331_01","status":"publish","type":"news","link":"http:\/\/web.brc.riken.jp\/ja\/archives\/news\/20260331_01","title":{"rendered":"\u30de\u30a6\u30b9\u907a\u4f1d\u5b50\u64cd\u4f5c\u306e\u7cbe\u5ea6\u3092\u98db\u8e8d\u7684\u306b\u5411\u4e0a<br><span style=\"font-size: 78%;\">\uff0d\u9ad8\u611f\u5ea6\u767a\u5149\u6280\u8853\u3067\u300c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6291\u5236\u6f0f\u308c\u300d\u3092\u6b63\u78ba\u8a55\u4fa1\uff0d<\/span>"},"content":{"rendered":"<section class=\"chapter\">\r\n  <p>\u7406\u5316\u5b66\u7814\u7a76\u6240\uff08\u7406\u7814\uff09\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08BRC\uff09<a href=\"https:\/\/mus.brc.riken.jp\/ja\/\">\u5b9f\u9a13\u52d5\u7269\u958b\u767a\u5ba4<\/a>\u306e\u4ef2\u67f4 \u4fca\u662d \u5c02\u4efb\u7814\u7a76\u54e1\u3001\u5409\u6728 \u6df3 \u5ba4\u9577\u3001\u75be\u60a3\u30b2\u30ce\u30e0\u52d5\u614b\u89e3\u6790\u6280\u8853\u958b\u767a\u30c1\u30fc\u30e0\uff08\u7814\u7a76\u5f53\u6642\uff09\u306e\u963f\u90e8 \u8a13\u4e5f \u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\uff08\u7814\u7a76\u5f53\u6642\u3001\u73fe iPS\u7d30\u80de\u9ad8\u6b21\u7279\u6027\u89e3\u6790\u7814\u7a76\u30c1\u30fc\u30e0 \u5ba2\u54e1\u4e3b\u7ba1\u7814\u7a76\u54e1\uff09\u3001\u8133\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u7d30\u80de\u6a5f\u80fd\u63a2\u7d22\u6280\u8853\u7814\u7a76\u30c1\u30fc\u30e0\u306e\u5bae\u8107 \u6566\u53f2 \u30c1\u30fc\u30e0\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3089\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30de\u30a6\u30b9\u907a\u4f1d\u5b50\u64cd\u4f5c\u306b\u304a\u3044\u3066\u898b\u904e\u3054\u3055\u308c\u3066\u304d\u305f\u554f\u984c\u70b9\u3067\u3042\u308b\u300c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6291\u5236\u6f0f\u308c\u300d\u306b\u3064\u3044\u3066\u3001<a href=\"\/ja\/archives\/news\/20260331_01#01\">\u9ad8\u611f\u5ea6\u767a\u5149\u6280\u8853\u30fbAkaBLI<sup>[1]<\/sup><\/a>\u3092\u5229\u7528\u3057\u3066\u6b63\u78ba\u306b\u8a55\u4fa1\u3057\u3001\u3055\u3089\u306b\u300c\u6f0f\u308c\u300d\u3092\u6291\u3048\u308b\u624b\u6cd5\u3092\u691c\u8a0e\u3057\u3001\u907a\u4f1d\u5b50\u64cd\u4f5c\u306e\u7cbe\u5ea6\u3092\u98db\u8e8d\u7684\u306b\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\r\n  <p>\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u4eca\u5f8c\u3001\u304c\u3093\u3084\u8133\u6a5f\u80fd\u306e\u7814\u7a76\u306a\u3069\u3001\u6975\u3081\u3066\u7cbe\u5bc6\u306a\u64cd\u4f5c\u304c\u6c42\u3081\u3089\u308c\u308b\u533b\u5b66\u30fb\u751f\u547d\u79d1\u5b66\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u3088\u308a\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u30c7\u30fc\u30bf\u306e\u53d6\u5f97\u3092\u53ef\u80fd\u306b\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\r\n  <p>\u4eca\u56de\u3001\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30de\u30a6\u30b9\u306e\u7279\u5b9a\u306e\u7d30\u80de\u3084\u7d44\u7e54\u306b\u304a\u3044\u3066\u884c\u3046<a href=\"\/ja\/archives\/news\/20260331_01#02\">Cre-loxP\u30b7\u30b9\u30c6\u30e0<sup>[2]<\/sup><\/a>\u306b\u3088\u308b\u907a\u4f1d\u5b50\u64cd\u4f5c\u3092\u3001\u4f53\u5916\u304b\u3089\u8a55\u4fa1\u3067\u304d\u308b<a href=\"\/ja\/archives\/news\/20260331_01#03\">\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9<sup>[3]<\/sup><\/a>\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8ee2\u5199\u30ec\u30d9\u30eb\u3067\u5236\u5fa1\u3059\u308b\u5f93\u6765\u306e\u624b\u6cd5\u3067\u306f\u3001\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3057\u306a\u3044\u3088\u3046\u5236\u5fa1\u3057\u305f\u72b6\u614b\u3067\u3082\u5fae\u91cf\u306a\u767a\u73fe\u304c\u8d77\u3053\u3063\u3066\u3057\u307e\u3046\u300c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6291\u5236\u6f0f\u308c\u300d\u304c\u3042\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u3053\u306e\u300c\u6f0f\u308c\u300d\u306f\u907a\u4f1d\u5b50\u64cd\u4f5c\u306e\u7cbe\u5ea6\u3092\u640d\u306a\u3046\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8ee2\u5199\u3068\u7ffb\u8a33\u306e2\u6bb5\u968e\u3067\u5236\u5fa1\u3059\u308b\u65b0\u305f\u306a\u624b\u6cd5\u3067\u306f\u300c\u6f0f\u308c\u300d\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u3001Cre-loxP\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308b\u907a\u4f1d\u5b50\u64cd\u4f5c\u3092\u4f53\u5916\u304b\u3089\u6b63\u78ba\u306b\u8a55\u4fa1\u3067\u304d\u308b\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9\u306e\u958b\u767a\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\r\n  <p>\u672c\u7814\u7a76\u306f\u3001\u79d1\u5b66\u96d1\u8a8c\u300e<span style=\"font-style: italic;\">Cell Reports Methods<\/span>\u300f\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff083\u670830\u65e5\u4ed8\uff1a\u65e5\u672c\u6642\u95933\u670831\u65e5\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<\/section>\r\n<section class=\"chapter\" style=\"margin-top:40px;\">\r\n<div class=\"_flex\">\r\n  <a href=\"https:\/\/www.riken.jp\/press\/2026\/20260331_1\/index.html\" target=\"_blank\" class=\"main-button\" rel=\"noopener noreferrer\"><span>\u7406\u5316\u5b66\u7814\u7a76\u6240 \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/span><\/a>\r\n<\/div>\r\n\r\n<hr>\r\n  <p>\u88dc\u8db3\u8aac\u660e<\/p>\r\n<a name=\"01\" id=\"01\"><\/a>\r\n<p style=\"font-size:85%;\"><sup>[1]<\/sup> \u9ad8\u611f\u5ea6\u767a\u5149\u6280\u8853\u30fbAkaBLI<br>\r\n\u30db\u30bf\u30eb\u306f\u300c\u30eb\u30b7\u30d5\u30a7\u30ea\u30f3\uff08\u5149\u308b\u7269\u8cea\uff09\u300d\u3068\u300c\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\uff08\u5149\u3089\u305b\u308b\u9175\u7d20\uff09\u300d\u306e\u53cd\u5fdc\u3067\u5149\u308b\u3002AkaBLI\u306f\u3001\u3053\u306e\u4ed5\u7d44\u307f\u3092\u4eba\u5de5\u7684\u306b\u6539\u826f\u3057\u3001\u5f93\u6765\u306e100\uff5e1,000\u500d\u3068\u3044\u3046\u5727\u5012\u7684\u306a\u660e\u308b\u3055\u3092\u5b9f\u73fe\u3057\u305f\u9ad8\u611f\u5ea6\u767a\u5149\u6280\u8853\u3067\u3042\u308b\u3002\u30eb\u30b7\u30d5\u30a7\u30ea\u30f3\u3068\u3057\u3066AkaLumine\u3068\u3044\u3046\u5149\u308b\u7269\u8cea\u3001\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\u3068\u3057\u3066Akaluc\u3068\u3044\u3046\u5149\u3089\u305b\u308b\u9175\u7d20\u3092\u4f7f\u7528\u3002AkaBLI\u306fAka bioluminescent imaging\u306e\u7565\u3002<\/p>\r\n<a name=\"02\" id=\"02\"><\/a>\r\n<p style=\"font-size:85%;\"><sup>[2]<\/sup> Cre-loxP\u30b7\u30b9\u30c6\u30e0<br>\r\n\u72d9\u3063\u305f\u5834\u6240\u3084\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u907a\u4f1d\u5b50\u3092\u81ea\u7531\u306b\u64cd\u4f5c\u3059\u308b\u305f\u3081\u306e\u3001\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u5b9a\u756a\u30c4\u30fc\u30eb\u3002Cre\u9175\u7d20\u306fDNA\u4e0a\u306e\u76ee\u5370\u3068\u306a\u308bloxP\u3092\u8a8d\u8b58\u3057\u3066\u3064\u306a\u304e\u5909\u3048\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u751f\u4f53\u5185\u306e\u7279\u5b9a\u306e\u5834\u6240\u3060\u3051\u3067\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30b9\u30a4\u30c3\u30c1\u3092\u300c\u30aa\u30f3\u30fb\u30aa\u30d5\u300d\u306b\u3067\u304d\u308b\u3002<\/p>\r\n<a name=\"03\" id=\"03\"><\/a>\r\n<p style=\"font-size:85%;\"><sup>[3]<\/sup> \u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9<br>\r\n\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9\u306f\u3001\u4f53\u5185\u3067\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u304c\u50cd\u304f\u5834\u6240\u3084\u6642\u9593\u3092\u3001\u5149\uff08\u86cd\u5149\u3084\u767a\u5149\uff09\u306b\u3088\u3063\u3066\u89b3\u5bdf\u3067\u304d\u308b\u3088\u3046\u306b\u6539\u826f\u3055\u308c\u305f\u5b9f\u9a13\u7528\u30de\u30a6\u30b9\u3002\u901a\u5e38\u3001\u3044\u3064\u30fb\u3069\u306e\u7d30\u80de\u3067\u907a\u4f1d\u5b50\u304c\u6d3b\u52d5\u3057\u3066\u3044\u308b\u304b\u3092\u898b\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u304c\u3001\u30ec\u30dd\u30fc\u30bf\u30fc\u907a\u4f1d\u5b50\u3092\u7d44\u307f\u8fbc\u3080\u3053\u3068\u306b\u3088\u3063\u3066\u305d\u306e\u907a\u4f1d\u5b50\u306e\u6d3b\u52d5\u3092\u77e5\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3053\u306e\u30de\u30a6\u30b9\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u751f\u547d\u73fe\u8c61\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u300c\u898b\u3048\u308b\u5316\u300d\u3067\u304d\u308b\u3002\u4eca\u56de\u306e\u30ec\u30dd\u30fc\u30bf\u30fc\u30de\u30a6\u30b9\u306f\u3001Akaluc\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u3088\u308aAkaluc\u30ec\u30dd\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u306e\u767a\u5149\u73fe\u8c61\u3092\u901a\u3057\u3066\u907a\u4f1d\u5b50\u64cd\u4f5c\u306e\u90e8\u4f4d\u3092\u89b3\u5bdf\u3067\u304d\u308b\u3088\u3046\u306b\u3057\u305f\u3082\u306e\u3002<\/p>\r\n<\/section>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_lmt_disableupdate":"","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"news_tag":[27],"division_tag":[33],"class_list":["post-12958","news","type-news","status-publish","hentry","news_tag-release","division_tag-mus","entry"],"acf":[],"_links":{"self":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12958","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news"}],"about":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/news"}],"version-history":[{"count":1,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12958\/revisions"}],"predecessor-version":[{"id":12961,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12958\/revisions\/12961"}],"wp:attachment":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=12958"}],"wp:term":[{"taxonomy":"news_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news_tag?post=12958"},{"taxonomy":"division_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/division_tag?post=12958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}