{"id":12459,"date":"2025-10-08T13:02:35","date_gmt":"2025-10-08T04:02:35","guid":{"rendered":"http:\/\/web.brc.riken.jp\/ja\/?post_type=news&#038;p=12459"},"modified":"2025-10-09T10:21:09","modified_gmt":"2025-10-09T01:21:09","slug":"20251008_01","status":"publish","type":"news","link":"http:\/\/web.brc.riken.jp\/ja\/archives\/news\/20251008_01","title":{"rendered":"\u5742\u53e3\u5fd7\u6587\u5148\u751f\u306e\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u53d7\u8cde\u306b\u5bc4\u305b\u3066"},"content":{"rendered":"<section class=\"chapter\">\r\n    <p>\u3053\u306e\u305f\u3073\u3001\u5927\u962a\u5927\u5b66\u514d\u75ab\u5b66\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08IFReC\uff09\u7279\u4efb\u6559\u6388 \u5742\u53e3\u5fd7\u6587\u5148\u751f\u304c\u3001\u514d\u75ab\u5bdb\u5bb9\u306e\u7dad\u6301\u6a5f\u69cb\u3092\u62c5\u3046\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u306e\u767a\u898b\u3068\u3001\u305d\u306e\u5206\u5b50\u57fa\u76e4\u306e\u89e3\u660e\u306b\u3088\u308a\u30012025\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3055\u308c\u307e\u3057\u305f\u3002\u5fc3\u3088\u308a\u304a\u795d\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\r\n    <p>\u5742\u53e3\u5148\u751f\u306f\u3001\u7c73\u56fd\u304b\u3089\u5e30\u56fd\u5f8c\u3001\u65b0\u6280\u8853\u4e8b\u696d\u56e3\uff08\u73fe\u30fb\u79d1\u5b66\u6280\u8853\u632f\u8208\u6a5f\u69cb\uff09\u3055\u304d\u304c\u3051\u7814\u7a76\u54e1\u3068\u3057\u3066\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u30e9\u30a4\u30d5\u30b5\u30a4\u30a8\u30f3\u30b9\u7b51\u6ce2\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u306e\u30e9\u30dc\u3067\u7814\u7a76\u3092\u7d9a\u3051\u3089\u308c\u30011995\u5e74\u306b\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066 CD4<sup>+<\/sup>CD25<sup>+<\/sup>T\u7d30\u80de\u306b\u3088\u308b\u81ea\u5df1\u514d\u75ab\u6291\u5236\u6a5f\u69cb\u3092\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/academic.oup.com\/jimmunol\/article-abstract\/155\/3\/1151\/8068613\">J. Immunol., 155:1151-1164<\/a>\uff09\u3002\u73fe\u5728\u306e\u7406\u7814\u7b51\u6ce2\u30ad\u30e3\u30f3\u30d1\u30b9\u3067\u3001\u3053\u306e\u3088\u3046\u306a\u6b74\u53f2\u7684\u767a\u898b\u306b\u3064\u306a\u304c\u308b\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u305f\u3053\u3068\u306f\u3001\u79c1\u305f\u3061\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u8a87\u308a\u3067\u3059\u3002<\/p>\r\n    <p>\u30ce\u30fc\u30d9\u30eb\u59d4\u54e1\u4f1a\u306e\u516c\u5f0f\u79d1\u5b66\u89e3\u8aac\uff08<a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/advanced-information\/\">Scientific Background 2025<\/a>\uff09\u3067\u306f\u3001\u3053\u306e1995\u5e74\u306e\u7814\u7a76\u3092\u300c\u6291\u5236\u6027T\u7d30\u80de\u767a\u898b\u306e\u30eb\u30cd\u30c3\u30b5\u30f3\u30b9\uff08the renaissance of suppressor T cell research\uff09\u300d\u3068\u4f4d\u7f6e\u3065\u3051\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6210\u679c\u3092\u7aef\u7dd2\u3068\u3057\u3066\u3001Foxp3\u907a\u4f1d\u5b50\u306e\u767a\u898b\uff08<a href=\"https:\/\/doi.org\/10.1038\/83784\">Brunkow et al., 2001<\/a>\uff09\u3084Treg\u5206\u5316\u6a5f\u69cb\u306e\u78ba\u7acb\uff08<a href=\"https:\/\/doi.org\/10.1126\/science.1079490\">Hori, Nomura, and Sakaguchi, 2003<\/a>\uff09\u3078\u3068\u767a\u5c55\u3057\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u30fb\u304c\u3093\u514d\u75ab\u306e\u7406\u89e3\u3068\u6cbb\u7642\u306b\u9769\u65b0\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002<\/p>\r\n    <p>\u5742\u53e3\u5148\u751f\u306e\u4e00\u9023\u306e\u767a\u898b\u306f\u3001\u3044\u305a\u308c\u3082\u5b9f\u9a13\u52d5\u7269\u30de\u30a6\u30b9\u306b\u3088\u308b\u7cbe\u7dfb\u306a\u514d\u75ab\u89e3\u6790\u304b\u3089\u751f\u307e\u308c\u305f\u6210\u679c\u3067\u3042\u308a\u3001\u52d5\u7269\u5b9f\u9a13\u306e\u79d1\u5b66\u7684\u30fb\u793e\u4f1a\u7684\u610f\u7fa9\u3092\u6539\u3081\u3066\u793a\u3059\u3082\u306e\u3067\u3059\u3002\u514d\u75ab\u306e\u6052\u5e38\u6027\u7dad\u6301\u3068\u3044\u3046\u8907\u96d1\u306a\u751f\u4f53\u53cd\u5fdc\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u5168\u8eab\u30ec\u30d9\u30eb\u3067\u514d\u75ab\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u518d\u73fe\u3067\u304d\u308b\u5b9f\u9a13\u52d5\u7269\u30e2\u30c7\u30eb\u306e\u89e3\u6790\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u4eca\u56de\u306e\u53d7\u8cde\u306f\u305d\u306e\u91cd\u8981\u6027\u3092\u793e\u4f1a\u306b\u5e83\u304f\u4f1d\u3048\u308b\u5951\u6a5f\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\r\n    <p>\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff08BRC\uff09\u306f\u3001\u30ca\u30b7\u30e7\u30ca\u30eb\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\uff08NBRP\uff09\u5b9f\u9a13\u52d5\u7269\u30de\u30a6\u30b9\u306e\u4e2d\u6838\u62e0\u70b9\u3068\u3057\u3066\u3001\u56fd\u5185\u3067\u958b\u767a\u3055\u308c\u305f\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u306f\u3058\u3081\u3001\u591a\u69d8\u306a\u7cfb\u7d71\u3092\u6574\u5099\u30fb\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u8fd1\u5e74\u306e\u5742\u53e3\u5148\u751f\u306e\u7814\u7a76\u306b\u304a\u3044\u3066\u3082\u3001\u672c\u5eb6\u4f51\u5148\u751f\uff082018\u5e74\u30ce\u30fc\u30d9\u30eb\u8cde\u53d7\u8cde\u8005\uff09\u304b\u3089\u5bc4\u8a17\u3055\u308c\u305fRbpj-flox\u30de\u30a6\u30b9\uff08<a href=\"https:\/\/brc.riken.jp\/mus\/RBRC01071\">RBRC01071<\/a>\uff09\u304c\u5229\u7528\u3055\u308c\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u3064\u306a\u304c\u308b\u753b\u671f\u7684\u306a\u6210\u679c\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\uff08<a href=\"https:\/\/doi.org\/10.1038\/s41586-025-08795-5\">Nature, 642:191-200, 2025<\/a>\uff09\u3002<\/p>\r\n    <p>\u4e16\u754c\u306e\u514d\u75ab\u5b66\u306e\u790e\u3092\u7bc9\u3044\u305f\u3054\u7814\u7a76\u304c\u3001\u3053\u3053\u7b51\u6ce2\u306e\u7406\u7814\u3067\u3082\u5c55\u958b\u3055\u308c\u3066\u3044\u305f\u3053\u3068\u3092\u6df1\u304f\u8a87\u308a\u306b\u601d\u3044\u307e\u3059\u3002\u5742\u53e3\u5148\u751f\u306e\u3054\u53d7\u8cde\u3092\u5fc3\u3088\u308a\u304a\u795d\u3044\u7533\u3057\u4e0a\u3052\u308b\u3068\u3068\u3082\u306b\u3001\u751f\u547d\u79d1\u5b66\u306e\u539f\u7406\u3092\u63a2\u7a76\u3059\u308b\u7814\u7a76\u3068\u3001\u305d\u308c\u3092\u652f\u3048\u308b\u6211\u304c\u56fd\u521d\u306e\u30de\u30a6\u30b9\u30ea\u30bd\u30fc\u30b9\u306e\u6574\u5099\u30fb\u767a\u5c55\u306b\u3001\u4eca\u5f8c\u3082\u5168\u529b\u3067\u53d6\u308a\u7d44\u3093\u3067\u307e\u3044\u308a\u307e\u3059\u3002<\/p>\r\n<p style=\"text-align: right;\">\u7406\u5316\u5b66\u7814\u7a76\u6240\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<br>\u30bb\u30f3\u30bf\u30fc\u9577<br>\u57ce\u77f3\u4fca\u5f66<\/p>\r\n<\/section>\r\n\r\n\r\n<section class=\"chapter\">\r\n  <h4 class=\"middleheading\"><a class=\"internal-link\" href=\"https:\/\/web.brc.riken.jp\/ja\/wp-content\/uploads\/news\/sakaguchi_nobel_2025.pdf\">\u5742\u53e3\u5fd7\u6587\u5148\u751f\u306e\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde 2025<br>\r\n&#8211; \u514d\u75ab\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u5b88\u308b\u5236\u5fa1\u6027T\u7d30\u80de\uff08Treg\uff09\u306e\u767a\u898b &#8211; <i class=\"fa-regular fa-file-pdf\"><\/i><\/a><\/h4>\r\n<\/section>\r\n\r\n<section class=\"chapter\">\r\n  <div class=\"_flex\">\r\n    <a href=\"https:\/\/www.riken.jp\/pr\/news\/2025\/20251007_2\/index.html\" target=\"_blank\" class=\"main-button\" rel=\"noopener noreferrer\"><span>2025\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306b\u3064\u3044\u3066\u306e\u4e94\u795e \u771f \u7406\u4e8b\u9577\u30b3\u30e1\u30f3\u30c8<\/span><\/a>\r\n  <\/div>\r\n<\/section>\r\n\r\n<section class=\"chapter\">\r\n  <div class=\"_flex\">\r\n    <a href=\"https:\/\/www.riken.jp\/pr\/news\/2025\/20251007_1\/index.html\" target=\"_blank\" class=\"main-button\" rel=\"noopener noreferrer\"><span>2025\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306b\u3064\u3044\u3066\u5929\u8c37 \u96c5\u884c \u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u9577\u306e\u30b3\u30e1\u30f3\u30c8<\/span><\/a>\r\n  <\/div>\r\n<\/section>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","_lmt_disableupdate":"no","_lmt_disable":"","footnotes":"","_wp_rev_ctl_limit":""},"news_tag":[25],"division_tag":[33],"class_list":["post-12459","news","type-news","status-publish","hentry","news_tag-notice","division_tag-mus","entry"],"acf":[],"_links":{"self":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news"}],"about":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/news"}],"version-history":[{"count":3,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12459\/revisions"}],"predecessor-version":[{"id":12466,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news\/12459\/revisions\/12466"}],"wp:attachment":[{"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=12459"}],"wp:term":[{"taxonomy":"news_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/news_tag?post=12459"},{"taxonomy":"division_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/ja\/wp-json\/wp\/v2\/division_tag?post=12459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}