{"id":10353,"date":"2024-04-26T09:00:14","date_gmt":"2024-04-26T00:00:14","guid":{"rendered":"http:\/\/web.brc.riken.jp\/en\/?post_type=news&#038;p=10353"},"modified":"2024-05-09T09:22:01","modified_gmt":"2024-05-09T00:22:01","slug":"20240426_01","status":"publish","type":"news","link":"http:\/\/web.brc.riken.jp\/en\/archives\/news\/20240426_01","title":{"rendered":"Superovulation with an anti-inhibin monoclonal antibody improves the reproductive performance of rat strains by increasing the pregnancy rate and the litter size"},"content":{"rendered":"<section  class=\"chapter\">\r\n<p>Rats are multiparous rodents that have been used extensively in research; however, the low reproductive performance of some rat strains hampers the broader use of rats as a biomedical model. In this study, the possibility of increasing the litter size after natural mating in rats through superovulation using an anti-inhibin monoclonal antibody (AIMA) was examined. In outbred Wistar rats, AIMA increased the number of ovulated oocytes by 1.3-fold. AIMA did not affect fertilization and subsequent embryonic development, resulting in a 1.4-fold increase in litter size and a high pregnancy rate (86%). In contrast, conventional superovulation by eCG\/hCG administration decreased the pregnancy rate to 6\u201340% and did not increase the litter size. In inbred Brown Norway rats, AIMA increased the litter size by 1.2-fold, and the pregnancy rate increased more than twice (86% versus 38% in controls). AIMA also increased the litter size by 1.5-fold in inbred Tokai High Avoiders and Fischer 344 rats. AIMA increased the efficiency of offspring production by 1.5-, 2.7-, 1.4-, and 1.4-fold, respectively, in the four rat strains. Thus, AIMA may consistently improve the reproductive performance through natural mating in rats, which could promote the use of AIMA in biomedical research. <\/p>\r\n<\/section>\r\n\r\n<section  class=\"chapter\">\r\n<div class=\"_flex\">\r\n  <a href=\"https:\/\/doi.org\/10.1038\/s41598-024-58611-9\" target=\"_blank\" class=\"main-button\" rel=\"noopener noreferrer\"><span><span style=\"font-style: italic;\">Scientific Report<\/span><br>\r\ndoi: 10.1038\/s41598-024-58611-9<\/span><\/a>\r\n<\/div>\r\n<\/section>","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"news_tag":[32],"division_tag":[35],"class_list":["post-10353","news","type-news","status-publish","hentry","news_tag-release","division_tag-kougaku","entry"],"acf":[],"_links":{"self":[{"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/news\/10353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/types\/news"}],"version-history":[{"count":1,"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/news\/10353\/revisions"}],"predecessor-version":[{"id":10356,"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/news\/10353\/revisions\/10356"}],"wp:attachment":[{"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/media?parent=10353"}],"wp:term":[{"taxonomy":"news_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/news_tag?post=10353"},{"taxonomy":"division_tag","embeddable":true,"href":"http:\/\/web.brc.riken.jp\/en\/wp-json\/wp\/v2\/division_tag?post=10353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}